Coenzyme Q10     (synonyms: Co Q10, Q10, Ubiquinone, Idebenone)

 

Discovery:  Coenzyme Q10 was first identified in 1957 by Dr. Frederick Crane, Wisconsin, U.S.A. Its chemical structure (C59H90O4) was determined in 1958.  Co Q10 is a compound made naturally in the body.  It is used by the cell’s mitochondria to produce energy for cell growth and maintenance.  It is also used by the body as antioxidant, which, can protect the damage caused by free radicals.  The damage caused by free radicals is believed to cause cancer.  Co Q10 level decreases as people getting older. 

 

The study of Co Q10 as a treatment for cancer began in 1961 and it never stop.  The fact is that the cancer patient’s Co Q10 level is significantly lower than normal people at the same age group. [7]  Peter Mitchell received the Nobel Prize in 1978 for his contribution to understand the biological energy transfer through the formulation of chemiosmotic theory, which includes the role of Co Q10 in energy transfer systems. [8,9,10,11]

 

Co Q10 facts:  energy production; electron and proton carrier; stabilize cell membranes; very strong antioxidant; all mammalian tissues need Co Q10; Beneficent for cancer, heart disease, gum disease, type 2 diabetics, migraine prevention, youthful skin, high blood pressure, Parkinson’s disease, kidney disease, renal disease, and against stroke [5]

 

Antioxidants:  including vitamins A, C, E, grapeseed extract, green tea, white tea, pomegranate, soy and Coenzyme Q10.  Antioxidants inhibit the skin damage caused by free radicals (skin-destroying elements by UV radiation and by smoking and other pollutants).  It is believed that 20 % of the aging process is genetic, 80% is caused by the external factors including free radicals.  [1]

 

Wrinkles  “The body’s CoQ10 levels decrease naturally with age as well as with stress and illness….  One study found that after 6 weeks of CoQ10 application to eye wrinkles known as crow’s feet, wrinkle depth was reduced by 27 %;  after 10 weeks of application, fine lines and wrinkles were decreased by 43 %.”  [2]

 

Sun damage:  “Idebenone [is believed to be] more potent and effective than vitamins A, C, and E at preventing sun damage.”  “It is one of the most effective antioxidants in skincare today and also one of the most potent of all wrinkle-cure antioxidants because it protects cells from deterioration.” [3]

 

American Celebrity Health Secrets:  “the newest trends in Hollywood to get skin looking great from the inside out…  Supplements containing antioxidants … coenzyme Q10 are excellent at helping to destroy free radicals, giving skin a younger looking appearance.”  [4]

 

Technology of the Future:  Idebenone, a derivative of Coenzyme Q10, was studied and shown to be more effective than vitamin E, Kinetin, vitamin C, and alpha lipoic acid….  [6]

 

 

 

Reference:

 

  1. “hydrate and treat;” Essence; Apr. 2005; 35, 12; Pg. 32; Academic Research Library
  2. “Topical products for aging skin;” Better Nutrition; Mar. 2005; 67, 3; Pg. 38; Health Module
  3. “Forgotten Frontier;” American Spa; Sep. 2005; 9, 9; Pg. 36;  ABI/INFORM Trade & Industry
  4. “Celebrity Health Secrets;” Total Health; Aug/Sep. 2004; 26, 4; Pg. 40; Health Module
  5. “AKT and the phosphatidylinositol 3-kinase/AKT pathway: Important molecular targets for Lung cancer Prevention and Treatment;” James A Crowell; Vernon E Steele; Journal of the National Cancer Institute; Feb. 19; 2003; 95, 4; Pg. 252; Health Module
  6. “The Science of skincare;” Heather Mikesell; American Spa; May 2004; 8, 5; Pg. 90; ABI/INFORM Trade & Industry
  7. http://www.cancer.gov/
  8. “Possible molecular mechanisms of the protonmotive function of cytochrome systems;” Mitchell P.; Journal of theoretical biology; 1976; vol. 62; Pg. 327-367
  9. “The vital protonmotive role of coenzyme Q;” Mitchell P.; Folkers K., Littarru G. P., Yamagami T. (eds); Biomedical and Clinical Aspects of Coenzyme Q10; 1991; vol. 6, Elsevier, Amsterdam; Pg. 3-10.
  10. “Respiratory chain system in theory and practice.” Mitchell P,; Advances in Membrane Biochemistry and Bioenergetic, Kim C. H., et al., Plenum Press, New York; 1988; Pg. 25-52.
  11. “Kelin’s respiratory chain concept and its chemiosmotic consequences.”  Mitchell P.; Science; 1979; vol. 206; Pg. 1148-1159.